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Synthesis of Mercaptobenzothiazole and Mercaptobenzimidazole Condensed with Inositol Derivatives
Author(s) -
de Assis João Vitor,
Couri Mara Rubia C.,
Porto Ricardo Silva,
de Almeida Wagner B.,
dos Santos Leonardo H. R.,
Diniz Renata,
Almeida Mauro V.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1096
Subject(s) - chemistry , inositol , epoxide , microwave irradiation , epoxy , condensation , antimicrobial , condensation reaction , organic chemistry , combinatorial chemistry , catalysis , receptor , biochemistry , physics , thermodynamics
This work describes the synthesis of inositol derivatives condensed with 2‐mercaptobenzothiazole or 2‐mercaptobenzimidazole, potential antimicrobial agents . These compounds were prepared by ring opening of epoxide intermediate (2 S ,3 R ‐epoxy‐1‐ O ‐methyl‐ l ‐ chiro ‐inositol and 2 R ,3 S ‐epoxy‐1‐ O ‐methyl‐ l ‐ chiro ‐inositol), which were obtained from l ‐quebrachitol (1‐ O ‐methyl‐ chiro ‐inositol). Microwave irradiation was used to promote the condensation reaction .