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Another Way to the Synthesis of 1,2,3‐Triazoles
Author(s) -
Xu Beihua,
Hu Yongzhou
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1095
Subject(s) - chemistry , methylhydrazine , acetic acid , elemental analysis , medicinal chemistry , proton nmr , organic chemistry , combinatorial chemistry , phenylhydrazine
The reactions of α‐bromoacetophenones with methylhydrazine in refluxing acetic acid generated 2‐methyl‐4‐aryl‐2 H ‐[1,2,3]triazoles in good yields. The method was developed by the reactions of α‐bromoacetophenones with phenylhydrazines in the presence of cupric ion, leading to 2,4‐diary‐2 H ‐[1,2,3]triazoles. The structures were established on the basis of corresponding IR, 1 H NMR, and elemental analysis data.
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