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A Simple and Environmentally Benign Nitration of Pyrazoles by Impregnated Bismuth Nitrate
Author(s) -
Ravi P.,
Gore Girish M.,
Tewari Surya P.,
Sikder Arun K.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1093
Subject(s) - nitration , chemistry , environmentally friendly , bismuth , nitrate , sulfuric acid , nitric acid , organic chemistry , biology , ecology
We report herein a facile, rapid, and environmentally friendly synthesis of nitropyrazoles in good yields using silica‐bismuth nitrate and silica‐sulfuric acid‐bismuth nitrate at room temperature for the first time. The relatively non‐toxic nature, ease of handling, easy availability, and low cost make the present procedure attractive for the nitration of a wide variety of diazoles in the drug and pharmaceutical industries.