Premium
Enaminone as Building Blocks in Organic Chemistry: A Novel Route to Polyfunctionally 2‐Substituted 5,6,7,8‐Tetrahydronaphthalenes and Their Antiviral Evaluation
Author(s) -
Hamdy Nehal A.,
ElSenousy Waled M.,
Fakhr Issa M. I.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1080
Subject(s) - chemistry , benzimidazole , pyridine , hydrazone , reagent , pyrazole , benzene , combinatorial chemistry , organic chemistry , medicinal chemistry
The enaminone 2 reacts with different reagents to afford anilino, aroylpyridine, 1,3,5‐tri‐tetrahydronaphthoyl‐benzene, pyridine, 2,3,6‐trisubstituted pyridines, pyrazole, pyrido[1,2‐ a ]benzimidazole, and hydrazone derivatives 4 , 6 , 8 , 9 , 11 , 13 , 15 , 17 , 20 , and 21 . The antiviral evaluation of some selected new products showed promising antiviral activity against human adenovirus 7 and human rotavirus Wa strain.