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Dimethylformamide Catalyzed Synthesis of Novel Heterocycles—Their Characterization and Antimicrobial Evaluation
Author(s) -
Dabholkar Vijay V.,
Patil Sunil R.,
Pandey Rajesh V.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1073
Subject(s) - chemistry , bicyclic molecule , aniline , antimicrobial , yield (engineering) , dimethylformamide , catalysis , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , materials science , metallurgy , solvent
Indandione 1 was brominated to yield 2‐bromoIndandione 2 , which further reacted with substituted thiocarbamides, carbamides, 2‐aminothiophenols, 2‐aminophenol, and triazole to furnished 3‐substituted aniline‐2‐thia‐4‐aza‐6,7‐benzo‐8‐oxo‐bicyclo[3.3.0]‐1(5),3‐octadiene 3 , 3‐substituted aniline‐2‐oxa‐4‐aza‐6,7‐benzo‐8‐oxo‐bicyclo[3.3.0]‐1(5),3‐octadiene 4 , 2‐Thia‐5‐aza‐9‐oxo‐3,4‐(3′‐substituted) benzo‐7,8‐benzo‐bicyclo[4.3.0]‐1(6) nonene 5 , 2‐oxa‐5‐aza‐9‐oxo‐(3, 4)‐(7,8)‐dibenzo‐bicyclo[4.3.0]‐1(6) nonene 6 , 3′‐substituted‐(1′,2′,4′)triazolo[5,6‐b][indeno(2,3‐e)]‐1,3,4‐thiadiazine 7 , respectively. The structures of compounds were elucidated on the basis of spectral techniques, further the representative compounds were screened for their antimicrobial activity .