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A Novel Series of 3,4‐Disubstituted Dihydropyrazoles: Synthesis and Evaluation for MAO Enzyme Inhibition
Author(s) -
Cardia Maria Cristina,
Sanna Maria Luisa,
Meleddu Rita,
Distinto Simona,
Yañez Matilde,
Viña Dolores,
Lamela Manuel,
Maccioni Elias
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1072
Subject(s) - chemistry , chalcone , diazomethane , monoamine oxidase , cycloaddition , aryl , enzyme , stereochemistry , combinatorial chemistry , computational chemistry , organic chemistry , catalysis , alkyl
In this study, the authors have designed and synthesized a novel series of 3-acyl-4-aryl-4,5-dihydropyrazoles,\udwith the aim to obtain new potential scaffolds for the inhibition of both isoforms of monoamine oxidase (MAO)\udenzyme. The synthetic pathway to these compounds includes as a key step the 1,3-dipolar cycloaddition reaction\udof diazomethane with a chalcone. All the compounds were fully characterized by means of spectroscopic and\udanalytical data and showed speci c inhibition against MAO A