A Novel Series of 3,4‐Disubstituted Dihydropyrazoles: Synthesis and Evaluation for MAO Enzyme Inhibition | Zendy

Cardia Maria Cristina | Zendy; Sanna Maria Luisa | Zendy; Meleddu Rita | Zendy; Distinto Simona | Zendy; Yañez Matilde | Zendy; Viña Dolores | Zendy; Lamela Manuel | Zendy; Maccioni Elias | Zendy

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A Novel Series of 3,4‐Disubstituted Dihydropyrazoles: Synthesis and Evaluation for MAO Enzyme Inhibition

Author(s) -

Cardia Maria Cristina,

Sanna Maria Luisa,

Meleddu Rita,

Distinto Simona,

Yañez Matilde,

Viña Dolores,

Lamela Manuel,

Maccioni Elias

Publication year - 2013

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.1072

Subject(s) - chemistry , chalcone , diazomethane , monoamine oxidase , cycloaddition , aryl , enzyme , stereochemistry , combinatorial chemistry , computational chemistry , organic chemistry , catalysis , alkyl

In this study, the authors have designed and synthesized a novel series of 3-acyl-4-aryl-4,5-dihydropyrazoles,\udwith the aim to obtain new potential scaffolds for the inhibition of both isoforms of monoamine oxidase (MAO)\udenzyme. The synthetic pathway to these compounds includes as a key step the 1,3-dipolar cycloaddition reaction\udof diazomethane with a chalcone. All the compounds were fully characterized by means of spectroscopic and\udanalytical data and showed speci c inhibition against MAO A

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