Premium
Pd‐Assisted Cross‐Coupling Reactions with 4‐Chlorocinnoline
Author(s) -
Heiter Helmut Julian,
Vilkauskaite Gyte,
Holzer Wolfgang
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1050
Subject(s) - chemistry , sonogashira coupling , cinnoline , coupling reaction , coupling (piping) , computational chemistry , chemical shift , combinatorial chemistry , medicinal chemistry , organic chemistry , palladium , catalysis , mechanical engineering , engineering
A series of 4‐ethynylcinnolines 3a – e was prepared by Sonogashira reaction of 4‐chlorocinnoline ( 1 ) with appropriate alkynes. Moreover, Suzuki coupling of 1 with boronic esters gave the corresponding 4‐arylcinnolines 5a – c . Detailed NMR spectroscopic data including unambiguous chemical shift assignments of all 1 H, 13 C, and 15 N resonances of the obtained cinnoline derivatives are reported.