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Catalyst‐Free Protocol for the Synthesis of Quinoxalines and Pyrazines in PEG
Author(s) -
Huang TieQiang,
Qu WenYan,
Ding JinChang,
Liu MiaoChang,
Wu HuaYue,
Chen JiuXi
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1043
Subject(s) - chemistry , quinoxaline , catalysis , polyethylene glycol , peg ratio , peg 400 , condensation , organic chemistry , combinatorial chemistry , physics , finance , economics , thermodynamics
A facile and simple catalyst‐free protocol has been developed for the condensation of 1,2‐diketones with aromatic 1,2‐diamines in polyethylene glycol (PEG), providing quinoxaline derivatives in good yields. The important features of the methodology are broad substrates scope, simple workup, catalyst free, environmentally benign, and no requirement for metal catalysts. It is noteworthy that the cyclization reaction of 1,2‐diketones with aliphatic 1,2‐diamines is also conducted smoothly to afford pyrazines in good yields under the standard conditions. In addition, PEG could be recovered easily and was reused without evident loss in activity