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An Effective, One‐Pot Synthesis of Fully Substituted Pyridines under Microwave Irradiation in the Absence of Solvent
Author(s) -
Yang XiaoHui,
Zhou YongHong,
Zhang PingHu,
Zhang LiYun
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1035
Subject(s) - chemistry , malononitrile , ammonium acetate , microwave irradiation , yield (engineering) , solvent , pyridine , organic chemistry , microwave , combinatorial chemistry , catalysis , high performance liquid chromatography , materials science , physics , quantum mechanics , metallurgy
A convenient, rapid, and environmentally benign protocol is described for the preparation of fully substituted pyridine derivatives via four‐component reactions between 2‐substituted acetophenones, aromatic aldehydes, malononitrile, and ammonium acetate under microwave irradiation with good yield and without solvent.