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Synthesis and Antitumor Evaluation of Some New Fused and Binary Pyridines
Author(s) -
Waly Mohamed A.,
ELHawary Ibrahim I.,
Hamama Wafaa S.,
Zoorob Hanafi H.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1020
Subject(s) - chemistry , acetylacetone , malononitrile , pyridine , combinatorial chemistry , organic chemistry , cytotoxicity , in vitro , medicinal chemistry , catalysis , biochemistry
Syntheses of some new heterocyclic compounds containing pyridone, thioxopyridine, halogenated‐pyridine‐carbonitriles, pyrazolopyridine, and pyridine derivatives were achieved. Besides, a modified synthetic method for the synthesis of 2‐chloro‐4,6‐dimethyl‐nicotinonitrile ( 3 ) through the reaction of acetylacetone and malononitrile as starting materials was implemented. The reaction of 2‐chloronicotinonitrile 3 with substituted amines to 2‐aminonicotinonitrile were also investigated. Fused or binary pyridines were tested for cytotoxicity against well‐known established model Ehrlich ascites cells in vitro . Compound 13 exhibited a high antitumor activity compared with 5‐fluorouracil.