Synthesis and Antitumor Evaluation of Some New Fused and Binary Pyridines | Zendy

Waly Mohamed A. | Zendy; ELHawary Ibrahim I. | Zendy; Hamama Wafaa S. | Zendy; Zoorob Hanafi H. | Zendy

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Synthesis and Antitumor Evaluation of Some New Fused and Binary Pyridines

Author(s) -

Waly Mohamed A.,

ELHawary Ibrahim I.,

Hamama Wafaa S.,

Zoorob Hanafi H.

Publication year - 2013

Publication title -

journal of heterocyclic chemistry

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.321

H-Index - 59

eISSN - 1943-5193

pISSN - 0022-152X

DOI - 10.1002/jhet.1020

Subject(s) - chemistry , acetylacetone , malononitrile , pyridine , combinatorial chemistry , organic chemistry , cytotoxicity , in vitro , medicinal chemistry , catalysis , biochemistry

Syntheses of some new heterocyclic compounds containing pyridone, thioxopyridine, halogenated‐pyridine‐carbonitriles, pyrazolopyridine, and pyridine derivatives were achieved. Besides, a modified synthetic method for the synthesis of 2‐chloro‐4,6‐dimethyl‐nicotinonitrile ( 3 ) through the reaction of acetylacetone and malononitrile as starting materials was implemented. The reaction of 2‐chloronicotinonitrile 3 with substituted amines to 2‐aminonicotinonitrile were also investigated. Fused or binary pyridines were tested for cytotoxicity against well‐known established model Ehrlich ascites cells in vitro . Compound 13 exhibited a high antitumor activity compared with 5‐fluorouracil.

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