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Polycyclic N ‐Heterocyclic Compounds 73: Synthesis and Evaluation of 5‐Substituted 1,2‐Dihydrofuro[2,3‐ c ]isoquinolines as Inducers of Lipoprotein Lipase mRNA Expression
Author(s) -
Okuda Kensuke,
Yoshida Masahiko,
Hirota Takashi,
Sasaki Kenji
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1016
Subject(s) - chemistry , isoquinoline , troglitazone , lipoprotein lipase , potency , lipase , inducer , stereochemistry , biochemistry , enzyme , in vitro , gene , peroxisome proliferator activated receptor
Several 5‐substituted 1,2‐dihydro[2,3‐ c ]isoquinoline derivatives were synthesized as part of our research to develop new diabetes drugs. Amines and sulfanyls were used as substituents at the 5th‐position. Evaluation of the effects of the newly synthesized compounds on lipoprotein lipase mRNA expression in 3T3‐L1 preadipocytes revealed one promising candidate with potency comparable to that of troglitazone.