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Synthesis of New 1,3,4‐Oxadiazol, Thiadiazole, 1,2,4‐Triazole, and Arylidene Hydrazide Derivatives of 4‐Oxo‐1,4‐dihydroquinoline with Antimicrobial Evaluation
Author(s) -
ElEssawy Farag A.,
ElSayed Wael A.
Publication year - 2013
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1005
Subject(s) - chemistry , hydrazide , antimicrobial , reagent , 1,2,4 triazole , combinatorial chemistry , triazole , condensation reaction , organic chemistry , medicinal chemistry , catalysis
A series of substituted 1,3,4‐oxadiazole, 1,2,4‐triazole, and 1,3,4‐thiadiazole derivatives of the substituted 3‐carboethoxy‐1,4‐dihydro‐4‐oxoquinoline have been synthesized through the reaction of the key intermediate thiosemicarbazide derivatives with different reagents. N ′‐Arylidene‐4‐oxo‐1,4‐dihydroquinoline‐3‐carbohydrazides were also synthesized through the condensation reaction of the corresponding hydrazides with the appropriate aldehydes. Antimicrobial activity of some of the synthesized compounds was evaluated.