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The first example of a regioselective Biginelli‐like reaction based on 3‐alkylthio‐5‐amino‐1,2,4‐triazole
Author(s) -
Chen Qiong,
Jiang LiLi,
Chen ChaoNan,
Yang GuangFu
Publication year - 2009
Publication title -
journal of heterocyclic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.321
H-Index - 59
eISSN - 1943-5193
pISSN - 0022-152X
DOI - 10.1002/jhet.1
Subject(s) - regioselectivity , chemistry , biginelli reaction , organic chemistry , condensation , solvent , condensation reaction , component (thermodynamics) , combinatorial chemistry , catalysis , physics , thermodynamics
The three‐component condensation of 3‐amino‐5‐alkylthio‐1,2,4‐triazoles with aromatic aldehydes and β‐ketoester was studied to develop a regioselective Biginelli‐like reaction. The results indicated that the reaction solvent and the properties of the β‐ketoester component displayed great influence on the regioselectivity. This is the first report about the regioselectivity of the aminotriazole‐based Biginelli‐like reaction. J. Heterocyclic Chem., (2009).