Premium
The effects of physical prehabilitation: Improved liver regeneration and mitochondrial function after ALPPS operation in a rodent model
Author(s) -
FardAghaie Mohammad H.,
Budai Andras,
Daradics Noemi,
Horvath Gergo,
Oldhafer Karl J.,
Szijarto Attila,
Fulop Andras
Publication year - 2021
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.945
Subject(s) - prehabilitation , liver regeneration , mitochondrial biogenesis , regeneration (biology) , hepatectomy , liver function , medicine , mitochondrion , sham surgery , endocrinology , surgery , andrology , biology , pathology , resection , microbiology and biotechnology , physiology , alternative medicine
Background To identify the role of physical prehabilitation (PP) in liver regeneration, mitochondrial function, biogenesis, and inflammatory response was investigated after associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) in a rodent model. Methods Male Wistar rats (n = 60) underwent ALPPS. Animals were divided (n = 30) to the physical prehabilitation group (PP) and sedentary group (S). The animals were exsanguinated before (0 hour) and 24, 48, 72, or 168 hours after the operation. Regeneration rate and proliferation index were assessed. Mitochondrial function, biogenesis, and inflammatory response were evaluated. Results Regeneration rate and Ki67 index were significantly increased in the PP group compared to the S group ( P < .001). Due to the changes in oxidative capacity and ATP production rate, the P/O ratio of PP group compared to the S group was significantly increased ( P < .05). PP group was characterized by accelerated mitochondrial biogenesis and less intense inflammatory response compared to the S group. Conclusions To our knowledge, this is the first demonstration of the beneficial effects of PP on liver regeneration, mitochondrial function, biogenesis, and the inflammatory response after ALPPS.