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A novel hydrogel sheet prevents postoperative pancreatic fistula in a rat model
Author(s) -
Kemmochi Akira,
Tamura Takafumi,
Shimizu Yoshio,
Owada Yohei,
Ozawa Yusuke,
Hisakura Katsuji,
Oda Tatsuya,
Kawano Yayoi,
Hanawa Takehisa,
Ohkohchi Nobuhiro
Publication year - 2021
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.867
Subject(s) - pancreatic fistula , amylase , lipase , medicine , parenchyma , fistula , polyvinyl alcohol , surgery , pancreas , chemistry , pathology , enzyme , biochemistry , organic chemistry
Aim To evaluate the efficacy of a novel hydrogel sheet in preventing postoperative pancreatic fistula (POPF). Background Postoperative pancreatic fistula is a life‐threatening complication. As no study has reported the use of hydrogel sheets in preventing POPF, their effectiveness for that purpose remains unclear. Methods A novel hydrogel sheet made of polyvinyl alcohol (PVA) was prepared by the freeze‐thaw method. The pancreatic ducts and surrounding pancreatic parenchyma of rats were transected to induce a pancreatic fistula. Next, the sheet was attached to the transection site. Ascitic fluid amylase and lipase concentrations were measured. Neoveil ® , a nonwoven polyglycolic acid (PGA) felt, is already clinically used as an absorbable reinforcing material at pancreatic transection sites. Neoveil ® was used for comparison, as was VIEWGEL ® , which is marketed as a wound dressing. Results The hydrogel sheet remained in place 48 hours postoperatively. The ascitic amylase concentrations in the control, VIEWGEL ® ‐treated, Neoveil ® ‐treated, and hydrogel‐treated rats, respectively, were 4992.4 ± 5355.7, 1068.4 ± 269.1, 730.2 ± 425.2, and 303.1 ± 240.1 IU/L; the ascitic lipase concentrations were 2279.8 ± 3395.2, 169.5 ± 100.6, 90.4 ± 71.0, and 86.8 ± 59.8 IU/L. The ascitic amylase and lipase levels were significantly lower in the hydrogel group than in the other groups ( P  < .05). Conclusions This novel hydrogel sheet effectively prevents pancreatic fistulas and has promising clinical application potential.

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