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Case series of 17 patients with cholangiocarcinoma among young adult workers of a printing company in J apan
Author(s) -
Kubo Shoji,
Nakanuma Yasuni,
Takemura Shigekazu,
Sakata Chikaharu,
Urata Yorihisa,
Nozawa Akinori,
Nishioka Takayoshi,
Kinoshita Masahiko,
Hamano Genya,
Terajima Hiroaki,
Tachiyama Gorou,
Matsumura Yuji,
Yamada Terumasa,
Tanaka Hiromu,
Nakamori Shoji,
Arimoto Akira,
Kawada Norifumi,
Fujikawa Masahiro,
Fujishima Hiromitsu,
Sugawara Yasuhiko,
Tanaka Shogo,
Toyokawa Hideyoshi,
Kuwae Yuko,
Ohsawa Masahiko,
Uehara Shinichiro,
Sato Kyoko Kogawa,
Hayashi Tomoshige,
Endo Ginji
Publication year - 2014
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.86
Subject(s) - medicine , bile duct , intrahepatic bile ducts , gastroenterology , incidence (geometry) , intrahepatic cholangiocarcinoma , biliary tract , intraepithelial neoplasia , cancer , prostate , physics , optics
Background An outbreak of cholangiocarcinoma occurred among workers in the offset color proof‐printing department at a printing company in J apan. The aim of this study was to clarify the characteristics of the patients with cholangiocarcinoma. Methods This was a retrospective study conducted in 13 J apanese hospitals between 1996 to 2013. The clinicopathological findings of cholangiocarcinoma developed in 17 of 111 former or current workers in the department were investigated. Most workers were relatively young. Results The cholangiocarcinoma was diagnosed at 25–45 years old. They were exposed to chemicals, including dichloromethane and 1,2‐dichloropropane. The serum γ‐glutamyl transpeptidase activity was elevated in all patients. Dilated intrahepatic bile ducts without tumor‐induced obstruction were observed in five patients. The cholangiocarcinomas arose from the large bile ducts. The precancerous or early cancerous lesions, such as biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile ducts, as well as non‐specific bile duct injuries, such as fibrosis, were observed in various sites of the bile ducts in all eight patients for whom operative specimens were available. Conclusions The present results showed that cholangiocarcinomas occurred at a high incidence in relatively young workers of a printing company, who were exposed to chemicals including chlorinated organic solvents.