Premium
Prediction of the progression of walled‐off necrosis in patients with acute pancreatitis on whole pancreatic perfusion CT
Author(s) -
Yamamiya Akira,
Kitamura Katsuya,
Yoshida Hitoshi,
Ishii Yu,
Mitsui Yuta,
Irisawa Atsushi
Publication year - 2020
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.803
Subject(s) - medicine , acute pancreatitis , perfusion , pancreatitis , retrospective cohort study , ultrasonography , nuclear medicine , radiology , blood volume , area under the curve , necrosis , gastroenterology
Background/Purpose This study investigated whether measuring pancreatic blood volume (PBV) on whole pancreatic perfusion computed tomography (P‐CT) can predict the progression of walled‐off necrosis (WON) in patients with acute pancreatitis (AP). Methods A single‐center, retrospective cohort study was conducted between December 2015 and December 2016. The participants were divided into two groups: 14 patients with WON and 15 patients without WON. PBV was measured within 72 hours after the diagnosis of AP, and the final diagnosis of WON was made by contrast‐enhanced CT (CE‐CT) or endoscopic ultrasonography (EUS) 4 weeks after the onset of AP. Results The minimum CT value did not differ significantly between the two groups. On the other hand, the minimum PBV was significantly lower in the WON group than in the without WON group (1.4 (0.9–9.9) vs 19.8 (8.2–21.7) mL/100 mL, respectively; P = .02). The cutoff value of the minimum PBV for WON was 16.5 mL/100 mL (sensitivity 100%, specificity 67%, AUC 0.85; P = .001). Conclusions Whole pancreatic P‐CT can evaluate pancreatic ischemia visually and quantitatively. The minimum PBV measurement on whole pancreatic P‐CT within 72 hours after the diagnosis of AP contributes to the prediction of progression of WON.