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Preoperative serum albumin is associated with intra‐abdominal infection following major hepatectomy
Author(s) -
Rungsakulkij Narongsak,
Vassanasiri Watoo,
Tangtawee Pongsatorn,
Suragul Wikran,
Muangkaew Paramin,
Mingphruedhi Somkit,
Aeesoa Suraida
Publication year - 2019
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.673
Subject(s) - medicine , odds ratio , confidence interval , perioperative , hepatectomy , logistic regression , albumin , receiver operating characteristic , area under the curve , gastroenterology , surgery , urology , resection
Background Major hepatectomy is a complex surgical procedure with high morbidity. Intra‐abdominal infection (IAI) is common following hepatectomy and affects treatment outcomes. This study was performed to investigate perioperative factors and determine whether the preoperative serum albumin level is associated with IAI following major hepatectomy. Methods From January 2008 to December 2018, 268 patients underwent major hepatectomy. We retrospectively analyzed demographic data and preoperative and perioperative variables. IAI was defined as organ/space surgical site infection. Risk factors for IAI were analyzed by logistic regression analysis. Results In total, 268 patients were evaluated. IAI was observed in 38 patients (14.6%). The mortality rate in the IAI group was 15.7%. Multivariate logistic analysis confirmed that the serum albumin level (odds ratio 0.91; 95% confidence interval 0.84–0.97; P = 0.03) and operative duration (odds ratio 1.50; 95% confidence interval 1.18–1.91; P < 0.01) were independent factors associated with IAI. A logistic model using the serum albumin level and operative duration to estimate the probability of IAI was analyzed. The area under the receiver operating characteristic curve for predicting IAI was 0.78. Conclusion The serum albumin level and operative duration were independent factors predicting IAI following major hepatectomy.