Molecular aspects of cholangiocarcinoma | Zendy

Kiguchi Kaoru | Zendy

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Molecular aspects of cholangiocarcinoma

Author(s) -

Kiguchi Kaoru

Publication year - 2014

Publication title -

journal of hepato‐biliary‐pancreatic sciences

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.63

H-Index - 60

eISSN - 1868-6982

pISSN - 1868-6974

DOI - 10.1002/jhbp.66

Subject(s) - receptor tyrosine kinase , erbb , carcinogenesis , cancer research , tyrosine kinase , signal transduction , medicine , computational biology , biology , cancer , microbiology and biotechnology

Novel targets for therapeutic or chemopreventive approaches against cholangiocarcinoma ( CCA ) are urgently needed. In this review article, we discuss the molecular aspects of CCA including the role of erbB receptor tyrosine kinases ( RTKs ), downstream signaling pathways of these erbB RTKs , inflammatory mediators during gallbladder carcinogenesis and bile acids based on our study using a mouse model for human CCA ( BK5 . erbB2 mice) as well as additional information in the literature.

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