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Molecular aspects of cholangiocarcinoma
Author(s) -
Kiguchi Kaoru
Publication year - 2014
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.66
Subject(s) - receptor tyrosine kinase , erbb , carcinogenesis , cancer research , tyrosine kinase , signal transduction , medicine , computational biology , biology , cancer , microbiology and biotechnology
Novel targets for therapeutic or chemopreventive approaches against cholangiocarcinoma ( CCA ) are urgently needed. In this review article, we discuss the molecular aspects of CCA including the role of erbB receptor tyrosine kinases ( RTKs ), downstream signaling pathways of these erbB RTKs , inflammatory mediators during gallbladder carcinogenesis and bile acids based on our study using a mouse model for human CCA ( BK5 . erbB2 mice) as well as additional information in the literature.