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Effect of Enhanced Recovery After Surgery program on pancreaticoduodenectomy: a randomized controlled trial
Author(s) -
Hwang Dae Wook,
Kim Hwa Jung,
Lee Jae Hoon,
Song Ki Byung,
Kim MyeongHwan,
Lee Sung Koo,
Choi Kyu Taek,
Jun InGu,
Bang JiYeon,
Kim Song Cheol
Publication year - 2019
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.641
Subject(s) - medicine , pancreaticoduodenectomy , confidence interval , clinical endpoint , randomized controlled trial , incidence (geometry) , surgery , single center , body mass index , resection , physics , optics
Background This study aims to investigate the noninferiority of Enhanced Recovery After Surgery ( ERAS ) for pancreaticoduodenectomy ( PD ). Methods In this single‐center trial, we randomly assigned 276 adult patients who underwent open PD into ERAS and conventional groups with 138 patients in each, from 2015 through 2017. The primary endpoint was the incidence of overall morbidity until postoperative 3 months. The secondary endpoints were in‐hospital or 30‐day mortality, postoperative length of stay (LOS), nutritional status and overall hospital costs. Results Overall morbidity was reported in 64 patients (52.0%, ERAS group) and in 68 patients (54.8%, conventional group) (risk difference [RD] −2.81 percentage points (pp); 90% two‐sided confidence interval −13.24 to 7.63). Mortality did not occur in any patients. The two groups did not differ significantly in median postoperative LOS (both 11 days; RD −8.46 pp), body mass index (22.4 ± 2.75 vs. 22.4 ± 2.65 kg/m 2 ; RD −3.48 pp), Patient‐Generated Subjective Global Assessment score over 4 (45 [40.5%] vs. 50 [43.1%] patients; RD −2.56 pp), and median overall hospital cost (15.61 vs. 16.04, ×10 6 KRW ; RD −6.08 pp). Conclusions Even in PD , modified ERAS protocol was not inferior to conventional protocol, while reducing treatment burden.