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Roles of liver fluke infection as risk factor for cholangiocarcinoma
Author(s) -
Sithithaworn Paiboon,
Yongvanit Puangrat,
Duenngai Kunyarat,
Kiatsopit Nadda,
Pairojkul Chawalit
Publication year - 2014
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.62
Subject(s) - opisthorchis viverrini , liver fluke , clonorchis sinensis , opisthorchis , clonorchiasis , opisthorchiasis , bile duct , incidence (geometry) , risk factor , liver cancer , bile duct cancer , medicine , environmental health , cancer , gastroenterology , immunology , helminths , physics , optics
Several factors are known to be associated with risk of cholangiocarcinoma ( CCA ) and infection with the liver flukes, O pisthorchis viverrini and C lonorchis sinensis , has often been singled out as the leading risk factor in east and southeast Asia. In this review, current knowledge of their biology, life cycle, and pathogenesis of O . viverrini , and its role as a carcinogenic parasite are presented. The trends of age‐specific incidence of liver cancer in Khon Kaen, northeast T hailand are considered and compared with the prevalence profiles of O . viverrini . Potential impacts of the liver fluke control program particularly by mass drug administration ( MDA ) and public health education in the past and a recent drop of incidence of CCA are discussed in relation to primary prevention and control of this fatal bile duct cancer.