Premium
Randomized controlled trial on timing and number of sampling for bile aspiration cytology
Author(s) -
Tsuchiya Tomonori,
Yokoyama Yukihiro,
Ebata Tomoki,
Igami Tsuyoshi,
Sugawara Gen,
Kato Katsuyuki,
Shimoyama Yoshie,
Nagino Masato
Publication year - 2014
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.61
Subject(s) - medicine , sampling (signal processing) , randomized controlled trial , laparotomy , cytology , surgery , gastroenterology , pathology , filter (signal processing) , computer science , computer vision
Background The issue on timing and number of bile sampling for exfoliative bile cytology is still unsettled. Methods A total of 100 patients with cholangiocarcinoma undergoing resection after external biliary drainage were randomized into two groups: a 2‐day group where bile was sampled five times per day for 2 days; and a 10‐day group where bile was sampled once per day for 10 days (registered University Hospital Medical Information Network/ ID 5983). The outcome of 87 patients who underwent laparotomy was analyzed, 44 in the 2‐day group and 43 in the 10‐day group. Results There were no significant differences in patient characteristics between the two groups. Positivity after one sampling session was significantly lower in the 2‐day group than in the 10‐day group (17.0 ± 3.7% vs. 20.7 ± 3.5%, P = 0.034). However, cumulative positivity curves were similar and overlapped each other between both groups. The final cumulative positivity by the 10th sampling session was 52.3% in the 2‐day group and 51.2% in the 10‐day group. We observed a small increase in cumulative positivity after the 5th or 6th session in both groups. Conclusions Bile cytology positivity is unlikely to be affected by sample time.