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Validation of the albumin–indocyanine green evaluation model in patients with resected hepatocellular carcinoma and comparison with the albumin–bilirubin score
Author(s) -
Russolillo Nadia,
Forchino Fabio,
Conci Simone,
Mele Caterina,
Langella Serena,
Ruzzenente Andrea,
Scoleri Iolanda,
Giuliante Felice,
Guglielmi Alfredo,
Ferrero Alessandro
Publication year - 2019
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.597
Subject(s) - medicine , indocyanine green , hepatocellular carcinoma , ascites , albumin , gastroenterology , alice (programming language) , bilirubin , cohort , incidence (geometry) , surgery , art , physics , optics , art history
Background The albumin–indocyanine green evaluation ( ALICE ) model based on serum albumin and indocyanine retention rate has been shown to be an effective method for predicting postoperative outcomes in hepatocellular carcinoma patients. Aim of the study was to validate the ALICE model in a large Western cohort of patients by comparing the albumin–bilirubin ( ALBI ) score and Child–Turcotte–Pugh ( CTP ) score. Methods A total of 400 patients who underwent hepatic resection from January 2005 to June 2016 at three centers were enrolled. The ALICE , ALBI , and CTP scores were computed for all patients. Results The ALICE score correlated better with ALBI ( r = 0.428) than with CTP score ( r = 0.302). Both the ALICE (grade 1: 49%; grade 2: 51%) and the ALBI (grade 1: 52.5%; grade 2: 47.5%) scores stratified the CTP class A patients into two distinct classes. The incidence of ascites (grades 1–3: ALICE 11%, 20%, 58%; ALBI 11%, 23%, 50%) and severe liver failure ( ALICE 8.7%, 10.5%, 41.7%; ALBI 8.6%, 12%, 50%) increased with increasing ALBI and ALICE grade and were similar for the same grade. Conclusions The ALICE model can assess hepatic functional reserve and predict postoperative outcomes with efficacy comparable with the ALBI grade and better than the CTP score.