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Preoperative assessment of frailty predicts age‐related events after hepatic resection: a prospective multicenter study
Author(s) -
Tanaka Shogo,
Ueno Masaki,
Iida Hiroya,
Kaibori Masaki,
Nomi Takeo,
Hirokawa Fumitoshi,
Ikoma Hisashi,
Nakai Takuya,
Eguchi Hidetoshi,
Kubo Shoji
Publication year - 2018
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.568
Subject(s) - medicine , hazard ratio , delirium , prospective cohort study , multivariate analysis , rehabilitation , checklist , confidence interval , physical therapy , intensive care medicine , psychology , cognitive psychology
Background Age‐related events, such as cardiopulmonary complications, delirium, transfer to a rehabilitation facility, and dependency are a major problem after hepatic resection in the elderly. This prospective multicenter study aimed to preoperatively evaluate frailty in the elderly according to a phenotypic frail index, named the “Kihon Checklist ( KCL ),” to predict “age‐related events” after hepatic resection. Methods Between May 2016 and September 2017, 217 independently living patients who consented among all patients aged ≥65 years who planned to undergo hepatic resection were included in the study. Preoperative frailty was defined as a total KCL score ≥8. We analyzed clinical characteristics and outcomes, including age‐related events (major respiratory and cardiac complications, delirium medication needed, transfer to rehabilitation facility, and dependency) between patients with and without frailty. Results Of the 217 patients, 63 and 154 were classified into the frail and non‐frail groups, respectively. The incidences of age‐related events (31.7% vs. 7.8%, P < 0.001) were higher in the frail group. Multivariate analysis indicated that frailty ( P < 0.001, hazard ratio 5.16) and resection of ≥2 sectors ( P = 0.014, hazard ratio 2.98) were independent risk factors for age‐related events. Conclusions Frailty evaluated by KCL in the elderly can predict postoperative age‐related events after hepatic resection.