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Safety and feasibility of liver resection with continued antiplatelet therapy using aspirin
Author(s) -
Monden Kazuteru,
Sadamori Hiroshi,
Hioki Masayoshi,
Ohno Satoshi,
Saneto Hiromi,
Ueki Toru,
Yabushita Kazuhisa,
Ono Kazumi,
Sakaguchi Kousaku,
Takakura Norihisa
Publication year - 2017
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.461
Subject(s) - aspirin , medicine , perioperative , diabetes mellitus , hepatectomy , resection , surgery , endocrinology
Background Aspirin is widely used for the secondary prevention of ischemic stroke and cardiovascular disease. Perioperative aspirin may decrease thrombotic morbidity, but may also increase hemorrhagic morbidity. In particular, liver resection carries risks of bleeding, leading to higher risks of hemorrhagic morbidity. Our institution has continued aspirin therapy perioperatively in patients undergoing liver resection. This study examined the safety and feasibility of liver resection while continuing aspirin. Methods We retrospectively evaluated 378 patients who underwent liver resection between January 2010 and January 2016. Patients were grouped according to preoperative aspirin prescription: patients with aspirin therapy (aspirin users, n = 31); and patients without use of aspirin (aspirin non‐users, n = 347). Results Aspirin users were significantly older ( P < 0.001), with a higher proportion of males ( P < 0.001) and higher frequencies of hypertension ( P = 0.004) and diabetes mellitus ( P < 0.001). No significant differences were observed in intraoperative parameters. Although the frequency of major morbidity tended to be higher among aspirin users than among aspirin non‐users, no significant difference was identified. No postoperative hemorrhage was seen among aspirin users. Conclusions Liver resection can be safely performed while continuing aspirin therapy without increasing hemorrhagic morbidity. Our results suggest that interruption of aspirin therapy is unnecessary for patients undergoing liver resection.