Premium
Clinical utility of bioimpedance analysis in liver cirrhosis
Author(s) -
Nishikawa Hiroki,
Enomoto Hirayuki,
Iwata Yoshinori,
Nishimura Takashi,
Iijima Hiroko,
Nishiguchi Shuhei
Publication year - 2017
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.455
Subject(s) - medicine , cirrhosis , multivariate analysis , univariate analysis , gastroenterology , body mass index , survival analysis , subgroup analysis , univariate , cutoff , muscle mass , cohort , multivariate statistics , surgery , meta analysis , statistics , mathematics , physics , quantum mechanics
Background The objective of the present study was to examine the impact of muscle mass depletion ( MMD ) as determined by data in bioimpedance analysis ( BIA ) in liver cirrhosis ( LC ) patients ( n = 382, 204 in male and 178 in female) on survival and to validate the utility of cutoff values in BIA recommended from current recommendations. Methods Muscle mass depletion was defined as patients with skeletal muscle mass index ( SMI ) using BIA <7.0 cm 2 /m 2 for male and <5.7 cm 2 /m 2 for female based on current recommendations. We retrospectively examined variables related to the presence of MMD using univariate and multivariate analyses and investigated the impact of MMD on survival. Results A total of 135 patients (35.3%) had MMD . Subjects were predominantly Child–Pugh A (278/382, 72.8%). For the entire cohort, the 5‐year cumulative survival rates were 59.8% in patients with MMD and 84.4% in patients without MMD ( P < 0.0001). In the multivariate analysis for survival, MMD revealed to be a significant adverse predictor for survival and for most subgroup analyses, the differences between MMD group and non‐ MMD group in terms of survival reached significance. Conclusion Muscle mass measurement using BIA may be helpful for LC patients and current recommendations were well verified in our analysis.