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Two‐dimensional shear wave elastography with propagation‐based reliability assessment for grading hepatic fibrosis and portal hypertension
Author(s) -
Maruyama Hitoshi,
Kobayashi Kazufumi,
Kiyono Soichiro,
Sekimoto Tadashi,
Kanda Tatsuo,
Yokosuka Osamu
Publication year - 2016
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.379
Subject(s) - elastography , medicine , transient elastography , portal hypertension , cirrhosis , hepatic fibrosis , receiver operating characteristic , grading (engineering) , nuclear medicine , liver fibrosis , fibrosis , gastroenterology , ultrasound , radiology , civil engineering , engineering
Background The aim of the present study was to examine the diagnostic ability of two‐dimensional shear wave elastography (2D‐SWE) with propagation‐based reliability for grading of hepatic fibrosis and portal hypertension. Methods This prospective study (UMIN000022838) consisted of 135 subjects. Phase I ( n = 40) examined the effect of standard deviation (SD)/median as the reliability criterion of 2D‐SWE, and phase II ( n = 95) compared the diagnostic ability of 2D‐SWE under the best SD/median value and transient elastography (TE). Results Phase I reported 0.49 as a best cut‐off SD/median value. In phase II, the elasticity showed a correlation between the 2D‐SWE and TE ( r = 0.88, P < 0.001). The area under the receiver operating characteristic curve (AUROC) was comparable between the 2D‐SWE and TE (0.936 and 0.948 for chronic hepatitis, P = 0.34; 0.939 and 0.956 for cirrhosis, P = 0.25). The hepatic venous pressure gradient showed a positive correlation with the 2D‐SWE ( r = 0.435, P = 0.043) and TE ( r = 0.378, P = 0.083) in 22 patients. The AUROC was comparable between the 2D‐SWE (0.844 for ≥10 mmHg, 0.838 for ≥12 mmHg) and TE (0.781 for ≥10 mmHg, P = 0.484; 0.800 for ≥12 mmHg, P = 0.589). Conclusions 2D‐SWE is promising for the assessment of the grade of hepatic fibrosis and portal hypertension, with the SD/median value as a reliability criterion.