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Redefining the R1 resection in patients with pancreatic ductal adenocarcinoma
Author(s) -
Markov Pavel,
Satoi Sohei,
Kon Masanori
Publication year - 2016
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.374
Subject(s) - pathological , resection margin , medicine , margin (machine learning) , pancreatectomy , pancreatic ductal adenocarcinoma , resection , adenocarcinoma , surgical margin , distal pancreatectomy , radiology , oncology , surgery , pancreatic cancer , pathology , cancer , machine learning , computer science
Most cases of pancreatic ductal adenocarcinoma (PDAC) are lethal. Margin‐negative surgical resection is a mainstay of treatment and the only chance of a cure. Differences in pathological reporting, surgical technique, definitions of resection margin, and group stratification all affect outcome analyses. Furthermore, there are controversial issues influencing the clinical interpretation of resection margin after pancreatectomy. There is no standardized definition of margin involvement in resected specimens of PDAC. The non‐standardized pathologic approach explains the wide range of positive resection margin rates (13–71%) that have previously been reported. A standardized pathologic evaluation needs to be developed for proper assessment of resection margin after oncologic pancreatectomy. This manuscript reviews the current controversial issues in assessing resection margin in order to enhance understanding of the current status and potential role of pathological evaluation in patients with PDAC.