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Comparison of clinicopathological characteristics between patients with occupational and non‐occupational intrahepatic cholangiocarcinoma
Author(s) -
Hamano Genya,
Kubo Shoji,
Takemura Shigekazu,
Tanaka Shogo,
Shinkawa Hiroji,
Kinoshita Masahiko,
Ito Tokuji,
Yamamoto Takatsugu,
Wakasa Kenichi,
Shibata Toshihiko
Publication year - 2016
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.353
Subject(s) - medicine , pathological , gastroenterology , bile duct , intrahepatic cholangiocarcinoma
Background An outbreak of cholangiocarcinoma has been reported among workers of an offset color proof‐printing department at a printing company in Japan. In this study, we compared the clinicopathological findings of this type of intrahepatic cholangiocarcinoma (occupational ICC) and non‐occupational ICC. Methods The clinical records of 51 patients with perihilar‐type ICC who underwent liver resection, including five patients with occupational ICC were retrospectively reviewed. The clinicopathological features were compared. Results In the occupational group, the patients were significantly younger ( P < 0.01), while serum γ‐glutamyl transpeptidase activity and the proportions of patients with regional dilatation of the bile ducts without tumor‐induced obstruction were significantly higher ( P = 0.041 and P < 0.01, respectively); the indocyanine green retention rate at 15 min was significantly lower ( P = 0.020). On pathological examinations, precancerous or early cancerous lesions, such as biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct, were observed at various sites of the bile ducts in all occupational ICC patients; such lesions were observed in only six patients in the control group ( P < 0.01). Conclusions The clinicopathological findings including age, liver function test results, diagnostic imaging findings, and pathological findings differed between the occupational and control groups.