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Pathological spectrum of bile duct lesions from chronic bile duct injury to invasive cholangiocarcinoma corresponding to bile duct imaging findings of occupational cholangiocarcinoma
Author(s) -
Kinoshita Masahiko,
Kubo Shoji,
Nakanuma Yasuni,
Sato Yasunori,
Takemura Shigekazu,
Tanaka Shogo,
Hamano Genya,
Ito Tokuji,
Terajima Hiroaki,
Yamada Terumasa,
Nakamori Shoji,
Arimoto Akira,
Fujikawa Masahiro,
Sugawara Yasuhiko,
Yamamoto Takatsugu,
Abue Makoto,
Nakagawa Kei,
Unno Michiaki,
Mizuguchi Toru,
Takenaka Kenji,
Shirabe Ken,
Shibata Toshihiko
Publication year - 2016
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.305
Subject(s) - bile duct , medicine , pathological , pathology , bile duct cancer , gastroenterology
Background We aimed to identify the pathological characteristics of occupational cholangiocarcinoma. Methods We examined the location and distribution of the carcinomas: atypical epithelium including biliary intraepithelial neoplasia (BilIN) and intraductal papillary neoplasm of the bile duct (IPNB); and chronic bile duct injuries in operative or autopsy liver specimens from 16 patients. We examined the detailed pathological findings and diagnostic imaging of three patients. Immunohistochemical analysis using primary antibodies against γH2AX and S100P was performed. Results BilIN and chronic bile duct injury were observed in 16 patients, and IPNB or invasive IPNB was observed in 11 patients. BilIN, IPNB, and/or chronic bile duct injury were observed in almost all the large bile ducts. Regional dilatation of the bile ducts without tumor‐induced obstruction revealed such pathological changes. Highly positive results for the γH2AX and S100P markers were noted in invasive carcinoma, BilIN, and IPNB, whereas positive results for γH2AX and negative results for S100P were noted in non‐neoplastic biliary epithelium. Conclusions The carcinogenic process of occupational cholangiocarcinoma comprised chronic bile duct injury and DNA damage in almost all the large bile ducts, along with induction of precancerous lesions and development of invasive carcinoma. Such pathological findings reflected radiological changes on diagnostic imaging.