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Efficacy of preoperative dexamethasone for postoperative nausea and vomiting after laparoscopic cholecystectomy: a large‐scale, multicenter, randomized, double‐blind, placebo‐controlled trial in Japan
Author(s) -
Wakasugi Masaki,
Tori Masayuki,
Shimizu Junzo,
Kim Yong Kook,
Noda Takehiro,
Dono Keizo,
Takeda Yutaka,
Yamamoto Tameyoshi,
Oshima Satoshi,
Morimoto Yoshikazu,
Asaoka Tadafumi,
Eguchi Hidetoshi,
Nagano Hiroaki,
Mori Masaki,
Doki Yuichiro
Publication year - 2015
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.285
Subject(s) - medicine , metoclopramide , nausea , postoperative nausea and vomiting , antiemetic , vomiting , dexamethasone , anesthesia , placebo , clinical endpoint , cholecystectomy , surgery , randomized controlled trial , alternative medicine , pathology
Background To assess the efficacy of preoperative dexamethasone for postoperative nausea and vomiting (PONV) after laparoscopic cholecystectomy (LC) in Japan. Methods A total of 270 patients at eight hospitals were randomized to receive dexamethasone 8 mg ( n = 136) or placebo ( n = 134) intravenously before LC. The primary endpoint was the degree of PONV and antiemetic requirements within 24 h after LC. Secondary endpoints were postoperative complications, postoperative hospital stay, and cost of hospital stay. This study was registered: UMIN‐CTR (UMIN3841). Results Within 6 h after LC, 17% (23/136) of patients in the dexamethasone group versus 24% (32/134) in the placebo group reported nausea ( P = 0.3), and 5% (7/136) versus 7% (10/134) reported vomiting ( P = 0.2). Metoclopramide 10 mg was used 0.09 ± 0.31 versus 0.14 ± 0.35 times ( P = 0.2). From 6 to 24 h, 10% (14/136) versus 13% (17/134) reported nausea ( P = 0.5), and 5% (7/136) versus 5% (7/134) reported vomiting ( P = 0.8). Metoclopramide was used 0.04 ± 0.19 versus 0.03 ± 0.17 times ( P = 0.8). Postoperative complications and postoperative hospital stay did not differ significantly between the two groups, but the cost of hospital stay was slightly higher in the dexamethasone group ( P < 0.05). Conclusions Routine use of preoperative dexamethasone for PONV after elective LC in Japan was not shown to have a clinical advantage.