Premium
Importance of resectability status in neoadjuvant treatment for pancreatic cancer
Author(s) -
Sho Masayuki,
Akahori Takahiro,
Tanaka Toshihiro,
Kinoshita Shoichi,
Nagai Minako,
Tamamoto Tetsuro,
Ohbayashi Chiho,
Hasegawa Masatoshi,
Kichikawa Kimihiko,
Nakajima Yoshiyuki
Publication year - 2015
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.258
Subject(s) - nat , medicine , pancreatic cancer , adjuvant , neoadjuvant therapy , chemotherapy , oncology , cancer , gastroenterology , group b , group a , surgery , breast cancer , computer network , computer science
Background Much attention has been paid to neoadjuvant treatment (NAT) as a new strategy especially for borderline resectable pancreatic cancer (BRPC). However, the optimal indication of NAT remains undetermined. Methods We analyzed 248 patients with pancreatic cancer (PC). One hundred resectable tumors were classified as R group. Sixty‐nine tumors with venous involvement were classified as BR‐P group, while 31 tumors with arterial involvement were classified as BR‐A group. Ninety‐nine patients received NAT. Furthermore, 48 unresectable locally advanced PC served as controls (LAPC group). Among them, 11 patients received adjuvant surgery afterwards (Ad‐surg group). Results The overall median survival time in the R, BR‐P and BR‐A groups was 45.3, 24.8 and 16.8 months. In the R and BR‐P groups, patients treated with NAT had a better prognosis than those without. In contrast, NAT had no impact on prognosis in the BR‐A group. Patients treated with NAT in the BR‐P, but not BR‐A group, had a better prognosis than patients in the LAPC group. Furthermore, patients in the Ad‐surg group had a significantly better prognosis than patients in the BR‐A group. Conclusions Borderline resectable pancreatic cancer with venous involvement, but without arterial involvement, may be a good indication for NAT. Our data highlight the importance of preoperative resectability assessment to evaluate the indication and efficacy of NAT.