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Serum profiles of M 30, M 65 and interleukin‐17 compared with C‐reactive protein in patients with mild and severe acute pancreatitis
Author(s) -
Vlachos Sotirios,
Tsaroucha Alexandra K.,
Konstantoudakis Georgios,
Papachristou Fotini,
Trypsianis Gregory,
Schizas Dimitrios,
Vaos Georgios,
Simopoulos Constantinos
Publication year - 2014
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.162
Subject(s) - acute pancreatitis , gastroenterology , medicine , pancreatitis , c reactive protein , prospective cohort study , plasma levels , interleukin 6 , inflammation
Abstract Background Several studies state that a test of severity early in the course of acute pancreatitis is still needed. In this prospective study, an assay of the biomarkers M 30 and M 65 as well as of interleukin 17 ( IL ‐17) is investigated. Methods One hundred and fifty patients and 70 controls were evaluated. The prognostic value of M 30, M 65 and their ratio M 30/ M 65 is assessed by ELISA . The same method is used for the study of IL ‐17. Results At 24 h after symptom onset, the concentrations of M 30 and M 65 as well as their ratio, differed significantly in severe compared to mild disease ( P = 0.016). C‐reactive protein ( CRP ) was significantly higher ( P < 0.001) in severe pancreatitis on the same day. The sensitivity of M 65 to show severe acute pancreatitis at 24 h was 100% for values above the cut‐off point of 428.15 U/l. The sensitivity of CRP was 100% as well. Concerning IL ‐17, its concentrations were higher in patients than in the control group ( P < 0.001) in the first 24 h. Conclusions Plasma concentrations of M 65 and the M 30/ M 65 ratio can be useful in predicting the severity of acute pancreatitis as early as 24 h after the onset of symptoms. The rates of IL ‐17 early in the course of acute pancreatitis are indicative of the disease.