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Portal vein embolization using absolute ethanol: evaluation of its safety and efficacy
Author(s) -
Igami Tsuyoshi,
Ebata Tomoki,
Yokoyama Yukihiro,
Sugawara Gen,
Takahashi Yu,
Nagino Masato
Publication year - 2014
Publication title -
journal of hepato‐biliary‐pancreatic sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.63
H-Index - 60
eISSN - 1868-6982
pISSN - 1868-6974
DOI - 10.1002/jhbp.113
Subject(s) - medicine , fibrin glue , embolization , portal vein embolization , radiology , nuclear medicine , surgery , hepatectomy , resection
Background Previously, we reported on the clinical efficacy and safety of portal vein embolization ( PVE ) with fibrin glue. Our embolic materials for PVE changed from fibrin glue to absolute ethanol ( EOH ) after 2001 due to prohibition of using fibrin glue for PVE . With introducing our technique of PVE with EOH , we evaluated its safety and efficacy with attention to the amount of EOH . Methods The medical records of 154 patients who underwent PVE using EOH were retrospectively reviewed. Results Changes with time in both the serum levels of aspartate aminotransferase ( AST ) and alanine aminotransferase ( ALT ) after PVE returned to the initial condition within 7 days after PVE . In the 96 patients who underwent CT volumerty 14 to 21 days after PVE , the volume of the embolized lobe decreased from 701 ± 165 cm 3 to 549 ± 148 cm 3 ( P < 0.0001). Meanwhile, the volume of the non‐embolized lobe increased from 388 ± 105 cm 3 to 481 ± 113 cm 3 ( P < 0.0001). On simple linear regression, the amount of EOH was positively correlated with both the maximum of AST and that of ALT after PVE ; however, it never correlated with changes in liver volume after PVE . Conclusions Portal vein embolization with EOH has a substantial effect on both hypertrophy of the non‐embolized lobe and atrophy of the embolized lobe. Quick recoveries of changes with time in AST and ALT after PVE proved that PVE with EOH is a safe procedure. The amount of EOH affected the extent of liver damage but had no clinical effects on changes in liver volume after PVE .