Open AccessLymphoplasmacytic lymphoma and marginal zone lymphoma involving bone marrow: A diagnostic dilemma. Useful clinicopathological features to accurate the diagnosis
Author(s) -
GarcíaAbellás Patricia,
Ferrer Gómez Ana,
Bueno Sacristán Diego,
Piris Villaespesa Miguel,
Talavera Yagüe María,
Reguero Callejas María Eugenia,
GarcíaCosío Mónica
Publication year - 2022
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.573
Subject(s) - lymphoplasmacytic lymphoma , pathology , bone marrow , medicine , lymphoma , biopsy , splenic marginal zone lymphoma , lymphocytosis , marginal zone b cell lymphoma , waldenstrom macroglobulinemia , marginal zone , spleen , b cell , immunology , antibody , splenectomy
Lymphoplasmacytic lymphoma (LPL) and marginal zone lymphoma (MZL) frequently infiltrate the bone marrowwith similar histologic and immunohistochemical characteristics posing diagnostic problems. Bone marrow biopsy specimens from 25 LPL and 16 MZL have been studied, correlating with clinical, laboratory parameters and the MYD88_p.L265P mutation. Paratrabecular and interstitial infiltration pattern, serum IgM paraprotein levels, and MYD88_p.L265P mutation were significantly more frequent in LPL. Nodular or intrasinusoidal pattern with lymphocytosis and splenomegaly were associated with MZL diagnosis. Different clinical and histological parameters should be collected when LPL or MZL is suspected in bone marrow biopsy specimens.