Open AccessImprovement in progressive multifocal leukoencephalopathy after pembrolizumab‐induced immune reconstruction inflammatory syndrome in a patient with follicular lymphoma
Author(s) -
Dufour Inès,
Duprez Thierry,
Wertz Marie,
Saussoy Pascale,
Ackermans Nathalie,
El Sankari Souraya,
van Pesch Vincent,
Van Den Neste Eric
Publication year - 2020
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.56
Subject(s) - progressive multifocal leukoencephalopathy , pembrolizumab , medicine , rituximab , bendamustine , jc virus , immune reconstitution inflammatory syndrome , follicular lymphoma , lymphoma , immune system , pathology , immunology , immunotherapy , virus , antiretroviral therapy , viral load
Progressive multifocal leukoencephalopathy (PML) may develop in follicular lymphoma patients treated with bendamustine‐rituximab. In this report, treatment with pembrolizumab successfully inhibited the clinical progression of PML by promoting radiologically demonstrated immune restoration inflammatory syndrome (IRIS), allowing complete clearance of the virus. These findings may further support the use of pembrolizumab in PML with special consideration for the potential occurrence of IRIS.