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Blastic plasmacytoid dendritic cell neoplasm (BPDCN) arising in the setting of polycythemia vera (PV): An illustration of the emerging role of flow cytometry analysis in monitoring progression of myeloproliferative neoplasms
Author(s) -
El Hussein Siba,
Yabe Mariko,
Wang Wei,
Pemmaraju Naveen,
Loghavi Sanam,
Jelloul Fatima Zahra,
Fang Hong,
Medeiros L. Jeffrey,
Burack W. Richard,
Evans Andrew G.,
Liesveld Jane L.,
Bennett John M.
Publication year - 2022
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.525
Subject(s) - polycythemia vera , myeloproliferative neoplasm , flow cytometry , medicine , pathology , polycythemia rubra vera , neoplasm , cancer research , myelofibrosis , immunology , bone marrow
This report highlights the value of flow cytometry analysis, particularly in the setting of myeloproliferative neoplasms showing features of progression, as neoplastic plasmacytoid dendritic cell (PDC) proliferations may be present, representing either a clonal expansion of mature PDCs related to the underlying myeloproliferative neoplasm or transformation to blastic plasmacytoid dendritic cell neoplasm (BPDCN). BPDCN should always be considered in patients with myeloid neoplasms in progression and/or who develop new cutaneous findings, as it may prompt change of management.

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