Open AccessAcquired factor VII inhibitor associated with primary central nervous system Lymphoma: A case report
Author(s) -
Goyal Vanshika,
Salmasi Giselle,
Leavitt Andrew D.,
Rubenstein James L.,
Banerjee Rahul
Publication year - 2022
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.482
Subject(s) - coagulopathy , primary central nervous system lymphoma , medicine , fresh frozen plasma , lymphoma , lumbar puncture , central nervous system , factor vii , pathology , surgery , coagulation , cerebrospinal fluid , platelet
Paraneoplastic coagulopathies are uncommon in patients with lymphoma. We report the first case of an acquired coagulopathy in a patient with isolated primary central nervous system lymphoma (PCNSL) demonstrating large‐cell histology. In our patient, a paraneoplastic factor VII inhibitor significantly delayed a diagnostic lumbar puncture despite fresh frozen plasma and inactivated prothrombin complex concentrate. While her coagulopathy was effectively overcome with recombinant activated factor VIIa and subsequently with lymphoma‐directed therapy, her delayed diagnosis likely contributed to a poor outcome. Our case highlights the importance of rapidly identifying and correcting paraneoplastic coagulopathies when PCNSL is suspected.