Open AccessHaematological malignancies in relatives of patients affected with myeloproliferative neoplasms
Author(s) -
Vanni Daniele,
Borsani Oscar,
Nannya Yasuhito,
Sant'Antonio Emanuela,
Trotti Chiara,
Casetti Ilaria Carola,
Pietra Daniela,
Gallì Anna,
Zibellini Silvia,
Ferretti Virginia Valeria,
Malcovati Luca,
Ogawa Seishi,
Arcaini Luca,
Rumi Elisa
Publication year - 2022
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.425
Subject(s) - medicine , cohort , genetic predisposition , myeloproliferative disorders , myeloproliferative neoplasm , oncology , disease , myelofibrosis , bone marrow
In a cohort of 3131 patients with myeloproliferative neoplasms (MPNs), we identified 200 patients (6.4%) who reported a second case of haematological malignancies (HM) in first‐ or second‐degree relatives. The occurrence of a second HM in the family was not influenced by MPN subtype, sex or driver mutation, while it was associated with age at MPN diagnosis: 8.5% of patients diagnosed with MPN younger than 45 years had a second relative affected with HM compared to 5.5% of those diagnosed at the age of 45 years or older ( p = 0.003), thus suggesting a genetic predisposition to HM with early onset.