Open AccessUnusual CD34 positivity in acute myeloid leukaemia with myelodysplasia‐related changes with megakaryoblastic differentiation
Author(s) -
Avenoso Daniele,
Krishnamurthy Pramila,
Salisbury Jonathan,
Rashid Sabia,
Gandhi Shreyans
Publication year - 2021
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.289
Subject(s) - immunophenotyping , cd34 , acute megakaryoblastic leukemia , immunohistochemistry , pathology , bone marrow , myeloid , myeloid leukaemia , medicine , myelodysplastic syndromes , precursor cell , biology , immunology , flow cytometry , stem cell , in vitro , genetics , biochemistry
Acute megakaryoblastic leukaemia is a rare entity with distinct immunophenotype profile and cytogenetic lesions. Herein, we report a case of acute myeloid leukaemia with myelodysplastic‐related changes with megakaryoblastic differentiation in absence of recurrent genomic lesions such as t(1;22), inv(3) and t(3;3). One of the peculiarities of this case is the positivity of CD34+ within the abnormal megakaryoblasts; CD61 immunohistochemistry highlights the heavily infiltration of bone marrow from abnormal megakaryoblasts.