Open AccessABO subgroup incompatibility with severe hemolysis after consecutive allogeneic stem cell transplantations
Author(s) -
Hecker Judith S.,
Wahida Adam,
Hameister Erik,
Filo Aneta,
Ruland Jürgen,
Bassermann Florian,
Hildebrandt Martin,
Verbeek Mareike,
Poeck Hendrik
Publication year - 2021
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.190
Subject(s) - abo blood group system , hemolysis , abo incompatibility , stem cell , medicine , immunology , biology , genetics
Allogeneic hematopoietic stem cell transplantations (HSCTs) represent a curative strategy for treating hematologic malignancies yet bear dangerous and frequently life‐threatening complications including the development of graft‐versus‐host disease. Here, we present a case of a patient that suffered from relapsed/refractory multiple myeloma, a hematologic neoplasm characterized by clonal proliferation of malignant plasma cells in the bone marrow. During the course of his disease, the patient underwent consecutive allogeneic HSCTs, during which he developed a clinical meaningful and hitherto unreported ABO subgroup incompatibility, leading to persistent hemolysis. Testing for ABO subgroups during donor selection, especially after consecutive allogeneic HSCTs, may therefore aid to prevent these complications.