z-logo
open-access-imgOpen Access
High serum ferritin alone as a predictor of mortality and hemophagocytic lymphohistiocytosis
Author(s) -
Kohli Shruti,
Chadha Ritu,
Rastogi Neha,
Yadav Satya Prakash
Publication year - 2021
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.153
Subject(s) - hemophagocytic lymphohistiocytosis , ferritin , serum ferritin , medicine , gastroenterology , immune system , immunology , disease
We report here utility of high serum ferritin alone as a predictor of mortality and diagnosis of hemophagocytic lymphohistiocytosis (HLH). We compared mortality in patients with high serum ferritin >5000 ng/mL versus <5000 ng/mL and looked for presence of HLH. Mortality was significantly higher ( P ‐value .0048) in patients with serum ferritin levels >5000 ug/dL. Of 21 patients with high serum ferritin, a median of three criteria were fulfilled to diagnose HLH. All patients had features of immune‐activation, and 76.2% patients had features of immune‐pathology favoring diagnosis of HLH. Serum ferritin can aid in prediction of mortality and help in the early diagnosis of HLH.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.
Having issues? You can contact us here