Open AccessAcquired platelet dysfunction in newly diagnosed myeloma
Author(s) -
Mortimer Joshua,
Gray Nicola,
Desborough Michael,
Baker Peter,
Kothari Jaimal,
Eyre Toby
Publication year - 2021
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.152
Subject(s) - dyscrasia , multiple myeloma , medicine , complication , platelet , bone marrow , clinical significance , biopsy , plasma cell dyscrasia , gastroenterology , plasma cell , pathology , surgery , immunology , immunoglobulin light chain , antibody
This is a case of an unexpected and dramatic bleeding complication in a patient post‐bone marrow biopsy performed for investigation of an IgA paraprotein with the results confirming multiple myeloma. Subsequent investigations were suggestive of an acquired platelet disorder indicated by abnormal platelet light aggregometry readings. It was observed that the impaired platelet aggregation corrected on reduction of the paraprotein load following commencement of antimyeloma treatment and plasma exchange. This case is of significant clinical relevance as it highlights a risk factor for serious complication in patients undergoing procedures in those with untreated plasma cell dyscrasias.