Open AccessAdult T cell leukaemia/lymphoma (ATL) in pregnancy: A UK case series
Author(s) -
Motedayen Aval Leila,
Boullier Mary,
Lyall Hermione,
Collins Graham P.,
Ayto Robert,
Kelly Dominic F.,
Tedder Richard S.,
Drysdale Simon B.,
Taylor Graham P.,
Cook Lucy B.
Publication year - 2021
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.142
Subject(s) - pregnancy , medicine , transmission (telecommunications) , serology , lymphoma , obstetrics , pediatrics , immunology , antibody , biology , telecommunications , genetics , computer science
Chronic infection with human T‐cell lymphotropic virus type‐1 (HTLV‐1) may result in aggressive adult T‐cell leukaemia/lymphoma (ATL) in 4‐6% carriers. The majority of this risk arises in carriers infected during infancy, and so each infant has ∼25% lifetime risk. Other risk factors include a family history of ATL. Antenatal HTLV‐1 screening is not undertaken in the UK. Methods Here we describe four cases of ATL diagnosed during pregnancy and describe strategies to minimise HTLV‐1 transmission to neonates. Results/conclusion These cases highlight undiagnosed HTLV‐1 in pregnancy which allows ongoing mother to child vertical transmission and risk of future ATL. We recommend the UK National Screening Committee incorporate HTLV‐1 serology into antenatal screening.