Open AccessAnaplastic large cell lymphoma as a posttransplant lymphoproliferative disorder in a renal transplant patient: A case report
Author(s) -
Alabdulbaqi Manar,
Toupin Melissa,
Berardi Philip,
McCurdy Arleigh
Publication year - 2020
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.13
Subject(s) - medicine , vincristine , lymphoma , anaplastic large cell lymphoma , etoposide , lymph node biopsy , post transplant lymphoproliferative disorder , cyclophosphamide , prednisone , lymph node , biopsy , chemotherapy , pathology , transplantation , rituximab
We report a case of a 45‐year‐old female who developed an ALK‐positive anaplastic large cell lymphoma (ALCL) 9 years after renal transplant. The patient underwent a cadaveric renal transplant for diabetic nephropathy, and presented 9 years later with fever and multiorgan dysfunction. The initial CT scans showed multiple enlarged supra‐ and infradiaphrgamatic lymph nodes. A CT‐guided core needle biopsy of a retroperitoneal lymph node revealed ALK positive ALCL. She received six cycles of cyclophosphamide, adriamycin, vincristine, etoposide, and prednisone, and has been in remission for over 3 years. Monomorphic T‐cell posttransplant lymphoproliferative disorder (PTLD) is an established but rare entity of PTLD and generally carries poor prognosis. This is a case report of a late PTLD with pathology reporting an aggressive T‐cell lymphoma that has been successfully treated with multiagent chemotherapy.