Open AccessFavorable prognostic phenotype in myelodysplastic syndrome with der(1;7)(q10;p10)
Author(s) -
Horio Tomohiro,
Enomoto Megumi,
Watarai Masaya,
Nakano Yuuta,
Yamada Saki,
Matsumura Saori,
Kanasugi Jo,
Takasugi Soichi,
Nakamura Ayano,
Uchino Kaori,
Mizuno Shohei,
Murakami Satsuki,
Yamamoto Hidesuke,
Hanamura Ichiro,
Takami Akiyoshi
Publication year - 2020
Publication title -
ejhaem
Language(s) - English
Resource type - Journals
ISSN - 2688-6146
DOI - 10.1002/jha2.115
Subject(s) - chromosomal translocation , medicine , dysplasia , phenotype , gastroenterology , abnormality , bone marrow , oncology , pathology , biology , gene , genetics , psychiatry
Unbalanced translocation der(1;7)(q10;p10) is a characteristic chromosomal abnormality in myelodysplastic syndrome (MDS). The current study revealed that among 13 MDS patients with der(1;7)(q10;p10), seven cases with no apparent dysplasia also had low numbers of myeloblasts in the bone marrow and a 3‐year survival rate of 86%; in contrast, the remaining six cases had a 3‐year survival rate of 0% ( P = .003). It was therefore suggested that MDS patients with der(1;7)(q10;p10) are classified into a distinct group with a favorable prognosis and another distinct group with a very poor prognosis.