Gene therapy for HIV infection: what does it need to make it work?
Author(s) -
von Laer Dorothee,
Hasselmann Susanne,
Hasselmann Klaus
Publication year - 2006
Publication title -
the journal of gene medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 91
eISSN - 1521-2254
pISSN - 1099-498X
DOI - 10.1002/jgm.908
Subject(s) - genetic enhancement , human immunodeficiency virus (hiv) , drug resistance , medicine , transgene , lentivirus , immunology , virology , gene , biology , viral disease , genetics
Abstract The efficacy of antiviral drug therapy for HIV infection is limited by toxicity and viral resistance. Thus, alternative therapies need to be explored. Several gene therapeutic strategies for HIV infection have been developed, but in clinical testing therapeutically effective levels of the transgene product were not achieved. This review focuses on the determinants of therapeutic efficacy and discusses the potential and also the limits of current gene therapy approaches for HIV infection. Copyright © 2006 John Wiley & Sons, Ltd.