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YTHDC1 gene polymorphisms and hepatoblastoma susceptibility in Chinese children: A seven‐center case–control study
Author(s) -
Chen Huitong,
Li Yong,
Li Li,
Zhu Jinhong,
Yang Zhonghua,
Zhang Jiao,
Li Suhong,
Xin Yijuan,
Xia Huimin,
He Jing
Publication year - 2020
Publication title -
the journal of gene medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 91
eISSN - 1521-2254
pISSN - 1099-498X
DOI - 10.1002/jgm.3249
Subject(s) - hepatoblastoma , genotype , odds ratio , haplotype , medicine , oncology , meta analysis , gastroenterology , biology , genetics , gene
Background Hepatoblastoma is a commonly occurring embryonal tumors in children. N6‐methyladenosine (m 6 A) plays a critical role in gene expression, thus contributing to the occurrence and progression of cancer. RNA splicing is regulated by the nuclear m 6 A reader YTHDC1 , yet the roles of YTHDC1 polymorphisms in hepatoblastoma remain unclear. Methods We conducted a seven‐center case–control study to determine the association between YTHDC1 gene polymorphisms (rs2293596 T>C, rs2293595 T>C and rs3813832 T>C) and hepatoblastoma susceptibility. We recruited 313 hepatoblastoma patients and 1446 healthy controls. Results There was no significant association between all of these polymorphisms and hepatoblastoma susceptibility in single locus or combined analysis. Stratification analysis revealed that rs2293596 TC/CC genotype carriers had a higher risk of developing hepatoblastoma in the subgroup of clinical stages III + IV [adjusted odds ratio (OR) = 1.80, 95% confidence interval (CI) = 1.18–2.76, p = 0.007]. In addition, 3 risk genotype carriers are more likely to develop hepatoblastoma in the subgroup of clinical stages III + IV (adjusted OR = 1.80, 95% CI = 1.18–2.76, p = 0.007). Furthermore, false‐positive probability analysis was used to notarize our findings. Haplotype analysis indicated that there was no significant association between inferred haplotypes of YTHDC1 gene based on observed genotypes and hepatoblastoma risk. Conclusions In conclusion, our findings suggest that the rs2293596 T>C polymorphism may contribute to hepatoblastoma susceptibly and YTHDC1 gene polymorphisms may have a cumulative effect on hepatoblastoma risk.