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The CYP17A1 gene polymorphisms are associated with hypercholesterolemia in Han Chinese
Author(s) -
Zhang Ning,
Chen Huimei,
Jia Jian,
Ye Xiaoman,
Ding Haixia,
Zhan Yiyang
Publication year - 2019
Publication title -
the journal of gene medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 91
eISSN - 1521-2254
pISSN - 1099-498X
DOI - 10.1002/jgm.3102
Subject(s) - cyp17a1 , single nucleotide polymorphism , odds ratio , confidence interval , minor allele frequency , allele , medicine , genetic association , genetics , endocrinology , biology , gene , genotype
Abstract Background The CYP17A1 gene has been identified to associate with hypertension in Chinese population. However, the association between CYP17A1 polymorphisms and hypertension‐related factors is unclear. The present study aimed to investigate the relation between CYP17A1 single nucleotide polymorphisms (SNPs) and serum lipid profiles. Methods In total, 1350 participants were included in the study. Six SNPs in or near CYP17A1 gene were genotyped in a Han Chinese population in two stages. Results There was a statistically significant association of rs1004467 (adjusted odds ratio = 0.783, 95% confidence interval = 0.667–0.919, p < 0.05) and rs11191548 (adjusted odds ratio = 0.788, 95% confidence interval = 0.672–0.925, p < 0.05) with hypercholesterolemia after adjustment for potential factors. Additionally, the rs1004467 minor G‐allele and the rs11191548 minor C‐allele were significantly associated with the lower serum total cholesterol levels ( p < 0.05 for all). Conclusions The rs1004467 and rs11191548 in the CYP17A1 gene are associated with a decreased risk of hypercholesterolemia and lower serum TC levels in Han Chinese.