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IL1R1 and IL1R2 polymorphisms were associated with tuberculosis risk: A pilot study
Author(s) -
Ren Guoxia,
Dong Qi,
Huyan Baojuan,
Jin Pu,
Chen Mingwei
Publication year - 2018
Publication title -
the journal of gene medicine
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.689
H-Index - 91
eISSN - 1521-2254
pISSN - 1099-498X
DOI - 10.1002/jgm.3057
Subject(s) - single nucleotide polymorphism , minor allele frequency , odds ratio , haplotype , allele , medicine , genetics , genotype , biology , gene
Background Interleukin (IL)‐1 has been reported to be involved in the development of tuberculosis (TB). IL1R1 and IL1R2 encode a cytokine receptor that belongs to the IL‐1 receptor family. However, few studies have reported on the polymorphisms of IL1R1 and IL1R2 in TB patients. Methods We investigated nine single‐nucleotide polymorphisms (SNPs) in IL1R1 and IL1R2 in 300 TB patients and 300 controls, aiming to evaluate their association with TB risk. Odds ratios and 95% confidence intervals were calculated using unconditional logistic regression after adjusting for age and gender. Results On comparing the allele frequencies of candidate SNPs, we found that the minor allele ‘A’ of rs4851527 in IL1R2 was associated with a decreased risk of TB, whereas the minor alleles of rs10490571, rs956730 and rs3917225 in IL1R1 were associated with an increased risk of TB ( p < 0.05). In the genetic model analysis, we found that the allele ‘A’ of rs4851527 was correlated with a decreased risk of TB in a log‐additive model, whereas the minor alleles of rs719250, rs3218977, rs10490571, rs956730 and rs3917225 were correlated with an increased risk of TB in dominant and log‐additive models ( p < 0.05). Additionally, we found three haplotypes that were associated with an increased risk of TB: TGCT and TGTT haplotypes constructed by rs11674595, rs4851527, rs719250 and rs3218896, as well as GA haplotype constructed by rs3218977 and rs2072472 ( p < 0.05). Conclusions Our data shed new light on the association between genetic polymorphisms of IL1R1 and IL1R2 and TB susceptibility in the Chinese Han population.